*=undergraduate student, **=graduate student, ***=post-doctoral associate

27. “Ni-Catalyzed Enantioselective Intramolecular Mizoroki–Heck Reaction for the Synthesis of Phenanthridinone Derivatives”Diana Rachii**, Dana J. Caldwell*, Yui Kosukegawa*, Mary Sexton**, Paul R. Rablen, and William P. Malachowski. Journal of Organic Chemistry 2023, 88, 8203–8226.

26.“Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Phenanthridinone Derivatives with an All-Carbon Quaternary Stereocenter” Mary Sexton**, William P. Malachowski, Glenn P. A. Yap, Diana Rachii**, Greg Feldman**, Andrew T. Krasley**, Zhilin Chen*, My Anh Tran*, Kalyn Wiley*, Alexandra Matei*, Samantha Petersen*, and Sabrina Tran Tien*. Journal of Organic Chemistry 2022, 87, 1154-1172.

25. “Palladium-catalyzed mono-γ-arylation of 7-methoxy-4-methylcoumarin” Mary E Sexton**, Ami Okazaki*, Zhuowen Yu*, Alexis van Venrooy*, Jason R Schmink, William P Malachowski. Tetrahedron Letters 2019, 60, 151057.

24. “Diaryl Hydroxylamines as Pan or Dual Inhibitors of Indoleamine 2,3-Dioxygenase-1, Indoleamine 2,3-Dioxygenase-2 and Tryptophan Dioxygenase” Maria Winters**, James B. DuHadaway, Khoa N. Pham, Ariel Lewis-Ballester, Shorouk Badir*, Jenny Wai***, Eesha Sheikh*, Syun-Ru Yeh, George C. Prendergast, Alexander J. Muller, William P. Malachowski. European Journal of Medicinal Chemistry 2019, 162, 455-464.

23. “Proton Spin-​lattice Relaxation in Organic Molecular Solids: Polymorphism and the Dependence on Sample Preparation” Peter A. Beckmann, Jamie, Ford, William P. Malachowski, Andrew R. McGhie, Curtis E. Moore, Arnold L. Rheingold, Gilbert J. Sloan, Gilbert J., Steven T. Szewczyk. ChemPhysChem 2018, 19, 2423-6.

22. “Catalytic Enantioselective Birch-​Heck Sequence for the Synthesis of Tricyclic Structures with All-​Carbon Quaternary Stereocenters” Andrew T. Krasley**, William P. Malachowski, Hannah M. Terz*, Sabrina Tran Tien*. Organic Letters 2018, 20, 1740-1743.

21. “Indoleamine 2,​3-​Dioxygenase and Its Therapeutic Inhibition in Cancer” George C. Prendergast, William P. Malachowski, Arpita Mondal, Peggy Scherle, Alexander J. Muller. International Review of Cell and Molecular Biology 2018, 336, 175-203.

20. “Discovery of IDO1 Inhibitors: From Bench to Bedside” George C. Prendergast, William P. Malachowski, James B. DuHadaway, Alexander J. Muller. Cancer Research 2017, 77(24), 6795-6811.

19. “Monitoring a simple hydrolysis process in an organic solid by observing methyl group rotation” Peter A. Beckmann, Joseph M. Bohen, Jamie Ford, William P. Malachowski, Clelia W. Mallory, Frank B. Mallory, Andrew R. McGhie, Arnold L. Rheingold, Gilbert J. Sloan, Steven T. Szewcyk, Xianlong Wang, Kraig A. Wheeler. Solid State Magnetic Resonance 2017, 85-86, 1-11.

18. “O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1” William P. Malachowski, Maria Winters^**, James B. DuHadaway, Ariel Lewis-Ballester, Shorouk Badir*, Jenny Wai, Maisha Rahman^*, Eesha Sheikh^*, Judith M. LaLonde, Syun-Ru Yeh, George C. Prendergast, Alexander J. Muller. European Journal of Medicinal Chemistry 2016, 108, 564-576.

17. “The first report of Lewis acid reagents in the intramolecular Rauhut–Currier reaction” Andrew T. Krasley** and William P. Malachowski. Tetrahedron Letters 2015, 56, 6073-6076.

16. “The Enantioselective Construction of Tetracyclic Diterpene Skeletons with Friedel-Crafts Alkylation and Palladium-catalyzed Cycloalkenylation Reactions” Sarah J. Burke**, William P. Malachowski, Sharan K. Mehta* and Roselyn Appenteng*. Organic & Biomolecular Chemistry 2015, 13, 2726-2744. 15. “Enantioselective synthesis of decalin structures with all-carbon quaternary centers via one-pot sequential Cope/Rauhut–Currier reaction “ Tina Morgan Ross**, Sarah J Burke**, William P Malachowski. Tetrahedron Letters 2014, 55(33), 4616-4618.

14. “The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1” Hollie E. Flick, Judith M. LaLonde, William P. Malachowski, Alexander J. Muller. International Journal of Tryptophan Research 2013, 6, 35-45.

13. “Enantioselective synthesis of bicarbocyclic structures with an all-carbon quaternary stereocenter through sequential cross metathesis and intramolecular Rauhut–Currier reaction” Yuan Qiao*, Sanjeev Kumar***, and William P. Malachowski. Tetrahedron Letters 2010, 51(19), 2636-2638.

12.”Structure Based Development of Phenyl-imidazole-derived Inhibitors of Indoleamine 2,3-Dioxygenase” Sanjeev Kumar***, Daniel Jaller, Bhumika Patel*, Judith M. LaLonde, James B. DuHadaway, William P. Malachowski, George C. Prendergast and Alexander J. Muller. J. Med. Chem. 2008, 51(16), 4968-4977.

11. “Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors” Sanjeev Kumar,*** William P. Malachowski, James B. DuHadaway, Judith M. LaLonde, Patrick J. Carroll, Daniel Jaller, Richard Metz, George C. Prendergast, and Alexander J. Muller J. Med. Chem. 2008, 51(6), 1706-1718.

10. “A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase” T. Banerjee, J.B. DuHadaway, P. Gaspari,** E. Sutanto-Ward, D.H. Munn, A.L. Mellor, W.P. Malachowski, G.C. Prendergast and A.J. Muller. Oncogene 2008, 27(20), 2851-2857 .

9. “The Enantioselective Synthesis of (-)-Lycoramine with the Birch-Cope Sequence” William P. Malachowski, Tapas Paul***, and Sophia Phounsavath*. J. Org. Chem. 2007, 72(18), 6792-6796.

*This article was one of the top twenty accessed articles in the Journal of Organic Chemistry during July-Sept. 2007.

8. “Exploration of the Enantioselective Birch-Cope Sequence for the Synthesis of Carbocyclic Quaternary Stereocenters” Tapas Paul***, William P. Malachowski, and Jisun Lee*. J. Org. Chem. 2007, 72(3), 930-937.

7. “The Enantioselective Birch-Cope Sequence for the Synthesis of Carbocyclic Quaternary Stereocenters. Application to the Synthesis of (+)-Mesembrine” Tapas Paul***, William P. Malachowski, and Jisun Lee*. Org. Lett. 2006 8(18), 4007-4010.

6. “Structure-Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase Inhibitors” Paul Gaspari**, Tinku Banerjee, William P. Malachowski, Alexander J. Muller, George C. Prendergast, James DuHadaway, Shauna Bennett* and Ashley Donovan*. J. Med. Chem. 2006, 49(2), 684-692.

5. “A New Cancer Immunosuppression Target: Indoleamine 2,3-Dioxygenase (IDO). A Review of the IDO Mechanism, Inhibition and Therapeutic Applications” William P. Malachowski, Richard Metz, George Prendergast and Alexander J. Muller. Drugs of the Future 2005, 30(9), 897-909.

4. “A general strategy for the synthesis of azapeptidomimetic lactams” Robert L. Broadrup**, Bei Wang** and William P. Malachowski. Tetrahedron 2005, 61(43), 10277-10284.

3. “Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors” Alexander J. Muller, William P. Malachowski, and George C. Prendergast. Expert Opin. Ther. Targets 2005, 9, 831-849.

2. “Sequential Birch reduction-allylation and Cope Rearrangement of o-anisic acid derivatives” William P. Malachowski and Marisha Banerji*. Tetrahedron Lett. 2004, 45(44), 8183-8185.

1.”The Synthesis of Azapeptidomimetic beta-Lactam Molecules as Potential Protease Inhibitors” William P. Malachowski, Chenyang Tie**, Katherine Wang*, and Robert L. Broadrup**. J. Org. Chem. 2002, 67(25), 8962-8969.

Doctoral and Post-doctoral publications

4. “Asymmetric Total Synthesis of (+)-Apovincamine and a Formal Synthesis of (+)-Vincamine. Demonstration of a Practical ‘Asymmetric Linkage’ between Aromatic Carboxylic Acids and Acyclic Substrates” Arthur G. Schultz, William P. Malahchowski and You Pan. J. Org. Chem. 1997, 62(5), 1223-1229.3. “The Chemistry of Phosphapeptides: Formation of Functionalized Phosphonochloridates Under Mild Conditions and Their Reaction with Alcohols and Amines” William P. Malachowski and James K. Coward. J. Org. Chem. 1994, 59(25), 7616-7624.

2. “The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogues of Glutamyl-gamma-glutamate” William P. Malachowski and James K. Coward. J. Org. Chem. 1994, 59(25), 7625-7634.

1. “Nature of the Rate-determining Steps of the Reaction Catalyzed by the Yersinia Protein-tyrosine Phosphatase” Zhong-Yin Zhang, William P. Malachowski, Robert L. Van Etten, and Jack E. Dixon. J. Biol. Chem. 1994, 269(11), 8140-8145.

Patents

5. “Imidazole derivatives as IDO inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases” Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N. Vahanian, Charles J. Link, Judith LaLonde, George Prendergast, Alexander Muller, William Malachowski. PCT Int. Appl., WO2009132238 2009.

4. “Preparation of benzochromenedione derivatives for use as IDO inhibitors” George C. Prendergast, William P. Malachowski, , Alexander J. Muller. PCT Int. Appl. WO2008115804 2008.

3.”Dithiocarbamates as IDO inhibitors and their preparation, pharmaceutical compositions and their use in the treatment of diseases” James B. Duhadaway, George C. Prendergast, William P. Malachowski, Alexander J. Muller. WO2007050963 2007.

2. “Novel IDO (indoleamine 2,3-dioxygenase) inhibitors and methods of use” George C. Prendergast, Alexander J. Muller, James B. Duhadaway, and William P. Malachowski. WO 2004094409 2004.

1.. “Novel methods for the treatment of cancer and viral infections” George C. Prendergast, Alexander J. Muller, James B. Duhadaway, and William P. Malachowski. WO2004093871 2004.